Normally, I would lead to the mounting screw pattern that would typically be on top and rear of PC case as those are aligned in one way. Since, you mentioned a different location and really the PSU doesn't matter here for the most part. Which, I offer I like "dual fan" cased PSUs. They'll work w/o difficulty in any arrangement. if your PSU has one fan, then should be "direct ordinated" , how does it work, IN or OUT. You want the fan blowing OUT as its intended to exhaust int. heat build-up. If yours is ordinated to blow towards "UP" and towards the mtrbd. and all it is, then the case fans come into play are that more important as they have to exhaust the heat build-up. Typical PC fan placement is frt. draws "IN" and rear pulls "OUT". In other words you want AIRFLOW to be productive, install as required. Any other fan is typically directional as it blows towards something or away, like the video card as example.
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I have a XFX 1000W PSU and the installation directions say "Depending on the type of computer case, correct mounting of the power supply will result with the fan side top cover facing the mainboard. This does not apply to all types of cases" My particular case and AzzA Genesis 9000 has the power supply mount on the bottom but at the front of the case. There is mesh grill with removable filter on the bottom of the steel chassis and below that a vented tub which is about 2 inches in depth. My question is should I have the PSU fan facing down toward this grill work or up which will make it facing the Hard drive cage which can contain 5 hard drives? My assumption is that it should be facing down.

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