Microsoft does not install current motherboard drivers. Your post didn't tell much about the machine so I can't suggest a current package.
I inserted a flash drive into my home computer and the computer didn't recognize the flash drive. I thought there was something wrong with my flash drive, but it worked with my office computer. When I tried plugging it back into my work computer the thing won't work at all. In fact, no computer can read it now. It's just a piece of junk now.
Then I had a flash card for my digital camera. When I plugged a flash card reader into the USB port, the reader won't read the card. Now the reader won't work on any other computer either. The flash card is safe though. I can read the flash card only if I plug the digital camera directly into the USB. I don't have a problem with other hardwares, like a printer, scanner, or webcam.
My computer was built by a fried and runs on Windows XP. He can't figure it out either. Is the promlem with his build or is the USB ''blowing out'' my flash drives/reader?