With no mention of what protection software or scans you've done I'll just note the usuals.
1. Housecall. Scan, remove what it finds.
2. Free AVG AntiSpyware. (same)
3. Run IEFIX (automates many usual repairs.)
There could be other issues but many details were left out such as machine age and whether you inspected the motherboard capacitors.
In closing one could eject your suspect entry with a power tool like HIJACKHIS but be aware that I will not tell how.
When starting up computer, many times I had to restart because desktop icon how showing up. Went to run msconfig and disconnect all startup except system and everyday 1 by 1 I put it back and it narrows down to OtZgAcer.exe, I only disconnect that and turn all on, no problem. I think its Acer Launcher Manifest file. How can I fix this as I want to startup Launcher Manager and SiS VGA Utilities with that OtZgAcer.exe. Pls HELP!
Acer laptop/Aspire 3000
Window XP Home Edition SP2
Mobile AMD Sempron
HOPE THIS HELPS