No mention of OS, what "vault" and more.
It's unlikely that you'll get a "do-this" answer.
As to registry damage, the brutal truth is that I've seen virus/trojan damage so severe that the cost in hours at the shop outstrip the cost of a reinstall. The owner always has the option to try to fix it item by item, but they burst into flames when hit with a bill for the hours it would take to fix it versus a reinstall.
Tell more and consider educating the owner about what behaviour allowed the parasites on the machine. This may be a lesson about computing practices.
know ive been asking about this for a while i tried those over programs and they dident work there were lots of trojans also i have run a diffrent program wich worked but it dident get rid of one and i also have the problem i went to the vault were it was kept clicked heal but got a action stop sign come up but with no writing telling me nothing also is there a program that removes old programs from the regstry keys automatly as this will free up a bit of mb in till this problem is fixed