The usual treatment is to run Spybot, Adaware and Housecall. Then use any other browser when you can since IE even with popup stoppers can't stop them all.
Recently updated to sp2, and every works. But when I get on the internet, in about 3 or 4 minutes. I get overwhelmed by pop ups from just one place. I the addy in restricted and added it to the pop up killer, Mcaffee and System mechanic and xp, and it still comes up any suggestions