Which SoundBlaster card do you have?
Which motherboard (and chipset) do you have? If you have a motherboard with a VIA or Nvidia Nforce chipset, have you installed the drivers?
Also, is DMA enabled on your hard drive?
I built my own PC that had an integrated sound card. When I tried to play music, the sound would cut out at times and was not very clean. In addition, it appears to "strain" the system by making my mouse clumsy and flicker when I am playing songs.
I bought a SoudnBlaster card thinking the sound card on the motherboars was cheap, but I am still getting the same problem. I disabled the original sound card in the system Bios. Still a problem. Any suggestions?