Opera crashing constantly, also "MIRAR" issue

Kay..

What stands out (the most) in your post is, "ran registry cleaners galore". We find registry cleaners tend to create more problems, than they solve. With hopes the registry cleaners "did no harm", try the below.

Using Internet Explorer, download the below tools. If you're prevented from doing so, you will need to use another computer and transfer them to yours. (Using a CD/DVD or Flash Drive)

Download and run the "Rkill" tool. You will only need to launch one of files, in order for Rkill to work. (Right-click and "Run as Administrator") If you have no success running Rkill.exe, try the next. When Rkill runs you will see a command prompt window similar to this. When one DOES work (immediately) run a Scan with Malwarebytes' Anti-Malware. (See below) Do NOT reboot after running Rkill.

Rkill.exe
Rkill.com
Rkill.scr
Rkill.pif

Rkill's purpose is to terminate offending / malicious processes. A more detailed explanation of what Rkill "does and doesn't do", can be found at the bottom of the Rkill download page.

You're also going to scan with Malwarebytes' Anti-Malware. The direct links for the installer and manual updater are listed below. To avoid any problems, rename the installer, prior to transferring it to your computer. Change it from mbam-setup.exe to kevin.exe. Don't forget to update, after the transfer.

Malwarebytes' Installer
http://www.besttechie.net/tools/mbam-setup.exe

Manual Update link
http://data.mbamupdates.com/tools/mbam-rules.exe

I would also recommend scanning with SUPERAntiSpyware. SUPERAntiSpyware FREE Edition can be downloaded from here.

If you run into any problems along the way, please post back and let us know ..
Carol