Could be a defective mouse or conflict with another pointing device. I've also seen some opticals be picky about the surface they are on. They tend to be jerky or not work at all unless you use a plain mat.
I have ACER TravelMate 260 with windows XP Professional Installed. I am having a problem with mouse pointer (cursor). It keeps going to the right on ALL applications - Internet Explorer, MS Word, Excel, etc. I can press escape and stop it temporarily, but it resumes after a short rest. It seems to be a problem with the mouse that I am using -logitech optical mouse, USB - however I am not sure. Any possible reasons and solutions? Please let me know. Thank you.