At my work I've got both Word and Outlook set to use Word as email editor open practically all day without any problems. But, then, Word doesn't try to save normal.dot; it just uses it. For security, I've set the 'ask for normal.dot to be replaced' checkbox checked and (at home) I've got this file read-only also.
If you don't mind about not using Word as email editor in Outlook, nor mind about normal.dot being replaced 'automatically' and without any good reason when you didn't change it, everything should be fine. But I shouldn't be happy in your circumstances.
The problem you mentioned in your last paragraph doesn't seem related to normal.dot. Better start a new thread for that. Do you really mean 'open Word from some documents' or do you mean 'opening most documents from Word'?