I am in my second year of using NOD32 from Eset and do not regret it one bit.
Symantec would my system to it's knees every time it did something. I fact my place of employment still uses it and I sometimes have to stop working when the scan is started (we are centrally managed and we get no say when the scans run)
McAfee was just a plain pain the a** to use.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic