And this is with software you wrote yourself or existing software?
Maybe try installing the latest .NET framework (http://www.microsoft.com/downloads/en/details.aspx?FamilyID=9cfb2d51-5ff4-4491-b0e5-b386f32c0992&displaylang=en)
I have a problem with my .Net framework initialization.
For nearly all new programs, and some old, it tells me that there is an initialization error, and that it cannot find the runtime for this application.
Please, as I am unexperienced in .Net etc, but am experienced at general computer issues, please post any help you can think of, in a clear and concise format.
Thank you ever so much in advance!