Oh, some more info...aside from shutting the computer off all that really happens is a ton of pop-ups and the computer seems to be running quite a bit slower. Not 100% sure of the origin of the infection...I'm pretty sure a co-worker is responsible for it.
I currently have a virus(es) that is proving difficult to get rid of. Any attempt to run a virus scan (tried using Panda and Adaware as well as an online scanner through F-Secure) usually ends up in the computer abruptly shutting off. Tried running the scanners in safe mode with the same result. Any suggestions?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic