Try this......since it's a serial mouse, boot up the computer and get into the bios/setup by pressing the DEL (or F1 or F2) key down a couple of times lightly while the first screen is showing up on the monitor.
Once you get in there, you will have to use the keyboard exclusively to move around with and make changes. Now go to the Integrated Peripherals area if you have one, or look at the MAIN or ADVANCED section depending on how your bios information is laid out.
Look for SERIAL PORT 1 AND SERIAL PORT 2 or COM 1 AND COM 2
Serial Mice always go on the Serial or Com 1 position, so make sure that it is ENABLED in the bios (usually at the 3something/IRQ 4 position)....then go to Save and Exit.
If that doesn't give you access to the Mouse, shut down and look at the back of the computer to see if you have two serial ports.....you may have the mouse hooked up to the wrong one so switch it to the other one, and reboot the computer
My mouse one day stopped working ive tried a new mouse and checking the connection inside the computer its fine. I try going to safe mode and stuff and it still dont work. Anyone know how to fix it. I am running windows xp proffessional. And it is a pentium 2 computer. Ive tried replacing the cables inside the computer to. This is a serial mouse. i tried on other computers and it works. But not on this computer. I tried checking the operating system for errors and it still is dead