And just out of curiosity, where did you come across these games in ISO image format?
At first I thought it was just Daemon Tool's mounted ISO games, but now other full-screen games are crashing my comp too. Not all of them, only some of them. It's really pissing me off. It crashes whenever I close the game. It does this for dozens of games.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic