You may want to start using Firefox since even Bill Gates exclaimed "I have had malware, (adware), that crap" on some home machines.
My advice is simple. Move out of the line of fire between malware writers and Microsoft.
As to removal, check the Virus and Security Forum if Adaware, Spybot, Stinger and Housecall doesn't remove it.
I'm getting hammered with pop-ups. I have anti-virus software, pop-up blockers, spyware stuff, along with the XP Service Pak 2, and I still get tons of pop-up. My laptop with Windows ME has no problem(wireless connection).
I was also told that my browser has been hijacked. Since I downloaded Spybot and Browser Hihjack Blaster,I've got some capabilities back on my browser, but I'm still experiencing some problems connecting to some links when clicking on them