Ah yes, the McAfee is the key here. They released an update that has been causing people everywhere grief. Look around a bit, and someone is likely to have come up with some solutions.
I have a Dell Latitude E6400 laptop running XP Pro.
When starting it up earlier today, it took an excessively long time to load. Then, once loaded, a series of error messages appeared related to Dell Control Point Connection Manager, Act!, Dell Security Device and Task Status, Roxio Creator (a runtime error), and Wireless Configuration (notification dll not registered...).
In addition, I have been unable to access/open System Restore, IE (a quick flash, then nothing), McAfee Security Center (nothing), Connection Manager/Wireless Netowrk (no internet connection), and the "Windows Key' on the keyboard does not work.
I have tried rebooting in Safe Mode but am still unable to do a SYstem Restore. I have also run SuperAntiSpyware (updated earlier today) but only got some typical Tracking Cookies.
I'm not quite sure what to try next. I would think if I somehow got System Restore to work, I could restore the configuration from a day or two ago but I can't get that to work.