Frequently, the best way to start such a computer cleanup is to restart the computer into Safe Mode, then run a scan of a few folders at a time. For example.. Start with the "My Documents" folder... Then move to the Windows folder, etc.. Badly infected computers will generally scan correctly in Safe Mode.
Hope this helps.
Gri
I have many problems with my system. When I try to run AVG anti-spyware, at the end of the scan I get a blue screen that give a message about newly installed hardware or software. And also I get constant pop-ups, IE closes out, and many processes that are runny and most likely are viruses.
All I'm really asking is what is my best solution? Should I get the hard drive cleaned and scanned by a proffesional or what other actions?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic