Do you click on apply or OK after making the changes?
I set my mouse wheel from (start menu->CTRL Panel->Mouse) it's settings to 5 lines (and also from Tweak UI) and on reboot it goes back to one line/its default. I have set it on both things mentioned above together or separately and the same results ar repeated. How can I let Windows (XP home edition with Servicec pack 1 and all other upudates) remember my settings? WHy does it forget in the 1st place?