what antivirus and spyware did you use? I would uninstall the mouse driver and let xp find it again.
My OS is xp. I am using Logitech Optik Mouse. On most of the Icons on my Desktop if I right click a drop window use to open but now with the right click on most icons all my desk top icon go blank & come back after a while. Checked Virus & spyware. No problem.

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