If I read your post correctly:
- This happens with different mice on different OS'es (say: Windows and Live Linux).
- So it's not a defective mouse, nor something (driver or setting) in the OS
- So it's the hardware inside the case, the only common factor. Try a wreless mouse, a PS/2-mouse (if it's a USB-mouse no) or the other way around, or a different motherboard.

Kees