Try a hardwire (USB) mouse and see if that works, first thing to try. If the wired mouse functions I'd be for getting a new wireless unit, preferably Logitech.
My Microsoft wireless mouse 5000 is acting up sometimes it's ok other times it will not respond and is very jerky it seems ok when first start up but deteriorates the longer the computer is on, I am also having trouble with I.E. constantly closing could be associated

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