It may be 'safer' to use, but the inherent problems in deleting 'obsolete' registry keys is still present...no application can say with 100% certainty that a given key/file is not needed. Thus, I'd use the custom scan instead, but System Restore should be able to reverse any problems it may cause.
The online free microsoft safety scanner cleaned up like 100 apparent registry issues
on my HP Vista Home Premium laptop. I have heard some horror stories about registry cleaners doing more
harm than good, should I be worried that I may have screwed something up by using
the safety scanner?
here's the link, try it and see how many issues it finds(you have to do full scan and use internet explorer)
Or is it safe because it's directly from Microsoft?
I am particularly worried about having some kind of issue next time I reboot, i.e.
if a crucial registry file was accidently moved/deleted.