Both are right, it depends on the circumstances. MOST of the time it can root out any pests without needing to resort to Safe Mode, but sometimes a pest buries itself so deep into the OS that Safe Mode is your only real hope of excising it short of formatting.
Of course I would argue that the better question to be asking here, is what are you doing that is making malware such an issue. Then the follow-up question of what can you do to eliminate this particular threat to your system's security. If you have to rely on the likes of malwarebytes to routinely clean your system of pests, then that should tell you there is something wrong. Would you simply accept the idea of someone breaking into your house regularly, maybe taking over your living room while you're asleep, and you kick them out in the morning just to have the cycle repeat again the following night? I highly doubt you would, so why you allow the same basic thing to happen with your computer is one of those things that baffles me about most people.
I just have a quick question concerning Malwarebytes. I have one friend that says that you should run Malwarebytes in safe mode and another one who says you don't have to. I'm just wondering what the correct answer is. Thank you in advance for your answers.