Take a look in the Account preferences and make sure that there is nothing in there that relates to the wireless mouse and is set to start at login.
Scour the Library, both yours (in your home folder) and the one on the Hard Drive for any traces of software.
Preferences and Application data are good places to start.
I have the wireless natural keyboard/mouse combo.
Just replaced the mouse with a logitech which I like better (laser)
I keep getting a pop-up warning that the batteries in the Microsoft Mouse are low. When that happens, I have to drag out the old mouse, put batteries in to get it to go away. It locks up everything until you do. The mac will not respond to the logitech mouse at all at this point.
I have uninstalled the Intelli-Mouse software, rebooted, verified disk, everything I can think of and it still keeps popping up. Even if I check the remind in 3 weeks, it still does it daily... unchecking it altogether does not work either.
I am using an intel mac mini with OSX 10.6.4 all updates are done. Any body have any suggestions? I love the keyboard, but I would rather use the logitech mouse. It's software seems to be awesome. It has learned tricks I didn't even know existed. If I could only teach it to kill the microsoft one, or at least disable that annoying warning message.