That kind of settings bank would vary for each customer, since they see lag differently. So I'm not really able to answer the question with certainty.
What I can say is that the game mode strips away some of the processing and quality of the picture in order to achieve the lack of lag, if that makes sense. So calibrating the TV is one effect of processing, while the game mode is a different processing goal altogether.
Option A is brilliant picture and picture quality
Option B strips some of that to avoid lag
So going into game mode, you'll lose some of the processing options. If you can still calibrate it with the limited options and be satisfied, that would be ideal - and take a pretty savvy calibration tech. But I won't say that it's not worth it, or can't be done. I just don't have any idea how well the result would turn out with the limited options left, and hoping that this explanation why a definitive answer isn't possible explains why.
Does that help?
Ive had this model for about 7 months now and I love it.
But There are some questions in regard to the settings of the T.V
I really only use the T.V for gaming (xbox 360) Now the issue Im having is that I want to actually play games on the tv without having to activate the "game mode" option. Though without "game mode" on I get the slightest bit of lag which can be horrible for fast paced games, so is there any settings or a way to calibrate the T.V so that I dont need to play in game mode and I wont get the lag?