That's not uncommon if you have just XP (without SP2 or firewalls) and connected to the Internet.
Here's an article but you do need to identity which worm infected the machine -> http://securityresponse.symantec.com/avcenter/venc/data/w32.sasser.b.worm.html
When I start my pc I get the message: Isass invalid handle. when I click ok the system will restart and gives me the same error again and again and it starts ok again

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