Many users complain when they have 2-3 case fans and other cooling, so it really depends on your situation. Offhand, I don't think you'll be happy. You can however and go ahead and see how it works for ya. You should consider added cooling and if your case or config allows for this, if not or very limited, do what is necessary to help yourself.
So I am thinking about buying a gtx 460 and getting around a 700w power supply. I just wanna know if I have only one fan in my tower (exhaust) will it and my pc be okay to run?