As to problems the answer must be yes. That is, folk have PC issues all the time and while I can't foresee any issue here, it can't be discounted. That said, I'd do this.
I have a windows 7 pro 32 bit machine. It has a 1tb drive with the operating system on it and a 250 gb drive as a 2nd drive. It's used for photos, music etc. This drive is just about full. My question is: can I replace this drive with a 1tb drive? Will there be any conflicts using this setup? I also have a 1tb external usb hard drive I use to backup the two internal drives. With the external drive plugged in, will there be any problems? That would be 3 tb's. I've read alot about the 2.2tb limit, but don't really fully understand it. Please don't confuse me to much lol. Thanks