Take a look here:
http://support.wdc.com/download/index.asp?cxml=n&pid=3&swid=53
They will lead you in the way you should go without the use of Ghost, although Ghost will also do what you want. WD has a program on the link that will copy your boot drive info over to the new drive and allow you to make it the new boot drive all ready to go. Read the info they provide and make sure you understand it before proceeding.