I am certainly not an expert in this area, but I have had good luck with Norton Internet Security (2005 and previous versions). They have anti-spam settings that you can personalize. I also use Incredimail for my e-mail.
Wish I could be of more help!
My mother's computer has a worm and she is using Incredimail. I have tried everything I can think of: Spyboy, McAfee, bitdefender, and some others even I can't remember. There still appears to be a worm within her Increidmail email. Is there anything else I can do? Also, how can I be sure this worm is removed completely? Thanks for any inquiries.