We'll have to wait and see. It definitively won't be a competitor to APS-C cameras, but the 4/3rds might take a little bit of a hit, if it's what they've billed it out to be.
Three things that give me apprehension:
1. 30x zoom is a long reach. The usual rule for shutter speeds is 1/focal length, which the HS10 is 720mm. Even with image stabilization, you'll want a higher shutter speed in the longer shots.
2. If you want an external flash then the only way you can use it is in manual mode. There is no TTL in the HS10.
3. With the case with all the really long super-zoom cameras, they have a much longer shutter lag. The 10-12X ones aren't bad, but the 20x and up cameras seem to have much longer times with shutter lag.
The HS10 looks like a terrific camera... and just might be the first fixed-lens megazoom that really competes with low-end DSLRs without actually being one itself.
The sensor is still point-and-shoot small (1/2.3) but I'm willing to give Fujifilm the benefit of the doubt right now. Perhaps their backlit CMOS sensor, combined with the latest image processing algorithms, will make the difference.
The lens is High Resolution super wide Fujinon 30x optical zoom (see on the simulator: http://www.infoborder.com/Digital_Camera_Test/FujifilmFinePixHS10?background=patak ) with manual (mechanical) zoom
In terms of features, one certainly can't ask for more. Okay - I'd really would have liked more resolution in the LCD and EVF. But I'll have to actually seem them in person before passing judgement.
I wonder what camera response is like? That's another area that still separates DSLRs from even the best point-and-shoot cameras.
On paper, the HS10 seems to blow away all other P&S megazooms - even the best from Canon and Panasonic. It would be absolutely fantastic if image quality and response were lifted out of the class entirely - creating a genuine "bridge" camera. The creation of micro four-thirds and other EVILs like the Samsung NX10 makes this absolutely necessary.
I say this not to be negative. But the HS10 is clearly intended to be a serious photographer's camera and one can buy a Panasonic G1 for not much more money. Granted, you need additional lenses with the G1 which is a big plus for this camera. But I think you know what I mean when I say there is now competition for Fujifilm that wasn't there two years ago.
If the HS10 delivers the goods in terms of image quality (What do you think? 80% of micro four-thirds? Halfway between the Canon SX20 and micro four-thirds?) then it will make a solid case for itself as an alternative to EVILs and maybe even low-end DSLRs. Here's hoping anyway.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic