You can go 2 ways:
1. Big is beautiful. Nothing wrong with Dell or HP/Compaq or Lenovo (ex-IBM). I associate Toshiba with laptops, not desktops. Sony is (was?) excellent in consumer electronics (including Playstation), but I wouldn't recommend the Sony VAIO line of PC's; they are a little bit too much Sony and not generic enough.
2. Local business assembling a computer to your needs. If they have a good tech and good service, there's nothing wrong with that also. You might be able to get good advice on what you need here, although it's possible that you'll find a salesperson trying to sell you more than you need because of his bonus earnings just as well.
Be sure you buy what you need. More costs money for nothing, less will hamper the use.
Factors to consider: CPU (no need for the fastest), video (no need for high end graphics for gamers), RAM (512 Mb DDR would be excellent), hard disk size (depends on your downloading habits), monitor (if you need a new one, 17" LCD is nice), DVD-burner or external hard disk for backup is rather necessary nowadays, 200 W Dolby 5.1 sound isn't 'pretty basic business need', although you might like it. I consider a wireless keyboard and mouse as luxury. A PSU with enough wattage is a good investment.
Hope this helps.
I have a clone E/Machine about on it's last leg. Had a Gateway a few years, did not like their service. Desktop probably fits my need best. Pretty basic business needs. Work on Dell all day, and fairly happy with it, but need something in home office. Should I just stay with Dell? or is HP? or Toshiba? or Sony? better. very NOVICE at computers.
KISS = Keep It Simple Stupid is my motto! LOL!
Anyone have suggestions?