The problem is that word "best." You may have to try a few systems before you find it.
http://www.bose.co.uk/home_audio/music_speakers/ for example lists some common speakers and the quality is good. There are many other makers, but with what you've written, no one should answer.
I'd go shopping and get in home demos.
Can I get some advice on what to look for in home theater for a room about 300 sq. ft.? Would a HTIB work in a room of this size? I have the TV alread (50-inch LCD) and am trying to figure out what would be best for theater AND music for the house.