A few ways. First I boot SAFE MODE and try there.
If not then I boot some Live CD/USB/DVD and remove it in another OS.
Read http://tips.oncomputers.info/archives2004/0401/2004-Jan-11.htm when I note it's not something we need to learn. Just use it like a power tool.
Hello!
This is regarding windows 10.
Recently, for some strange reason, I was unable to further update a program I've been using regularly. The update failed with the message that someone/something else was using the application.
I quickly determined nothing was using it, but found that the update.exe and the application.exe is not owned by me any longer. In fact, I can not even get access to view owners.
The Security tab on the application just says "Unable to display current owner". By pressing the "change" button next to this text, I'm sent to a tab where it just reads "You do not have permission to view or edit this object's permission settings".
So I googled, adding the option to right click folder and files and get a "take ownership" command. This works on the folder the application is in (worked the manual way as you regularly do as well), but it does not take ownership of the .exes as mentioned. I can't even quarantine them with my antivirus.
Copying the folder worked fine, and updating the program from my new, copied, folder worked perfectly, but the old folder remains, and I'd very much like to delete it.
P.S pretty sure this isn't cause by any malware, I run both eset nod 32 along with malwarebytes premium on my computer.
Any suggestions?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic