Hmm, I see support up to 10.5.x but did you notice those other software titles? Maybe Epson or those others have new versions?
http://www.epson.com/cgi-bin/Store/support/supDetail.jsp?BV_UseBVCookie=yes&oid=104830&prodoid=63075502&infoType=Downloads&platform=Macintosh
Did you try the new Epson Scan drivers?

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