I guess we have to go over why Windows Admin is a sham of security. Let me on a PC and I'll give myself an Admin account in less than 10 minutes.
So why isn't Truecrypt a solution?
Also, where do you keep an unencrypted backup as, well, the web is full of folk crying about their losses.
Bob
As mentioned in the question, I want to secure my external hard drive. What I mean by secure is very simple. The program I'm looking for should be protecting my data by asking a password for selected files and documents to access including opening, deleting, copying, cutting, etc.
One important issue is that this security should be available on every PC my external is plugged into. So that a person (borrowed or stole) won't be able to access the data on my hard drive without my permission (the password i put).
P.S: I read one topic similar to my question and an advice was TrueEncrypt but that program is useful only if the PC has admin permission. So it is not useful for me.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic