There is no definitive cure for this one. While the OS will work just fine with a proper install of motherboard drivers and will autorun, adding software such as DirectCD, InCD, Musicmatch and what else can eventually cause oddities. And no one has a clear road back.

Here's what I would try. Go get TWEAKUI and change the AUTORUN settings in that tool. Next I would boot SAFE MODE and remove all CDROMs found in the DEVICE MANAGER. On reboot, the drives are redetected and the default autorun is applied.