Sorry but I am not at all sure what you mean.
If iTunes is installed on this computer, do you know where it is installed? An iTunes shortcut isn't the software itself, it is just a shortcut that points to the software in the folder where it is installed. So where the shortcut is should not make any difference.
In any case, all my program shortcuts are on my Desktop, or in my Start Menu > All programs listing.
Let's be clear. When you install software it will be installed on a hard drive. Whether that hard drive is an SSD or whether it is the older spinning HDD is not relevant. If a system has two hard drives installed and connected inside the case, then it may be possible to install software on either hard drive. It may not be possible. Some software, (I can think of Adobe software and possibly Microsoft Office, but I might be in error there), will insist that their software is installed on the C Drive.
The C Drive is where the operating system is installed, in your case this is the SSD.
So, some software can be installed on a different drive. Some cannot. The installation process will often offer you the chance to change the 'default' installation location. If it does then you can try and install the software on the other drive. But it might fail, or you may not even get that option.
Shortcuts to these application will often be made, but those shortcuts are placed either on the Desktop or in the Start Menu, or even both.
That is software. But personal data, like music, documents, photos, videos, etc, they can be stored wherever you like, on either drive.