When it doesn't run simply rename the .exe file (task manager shows what that is - right click on the program in the processes list and choose to go to file location, at least in Windows 7).
Whatever starts it won't work anymore when it's no longer there.
I have discovered an unwanted app called IdleBuddy. Research showed me it loads my computer w/ads which slows down my computer. I have used malwarebytes, avast & emsissoft to try to get rid of it. I have to use task manager, when it opens, to just remove the icon from my taskbar. Sadly after a whole day of that & running cleandsk, it was back again this morning. Any suggestions on how to get rid of this permanently would be greatly appreciated!!