Dirtydust,
1. Do you have the latest Spybot (Vers. 1.3)? If not, go here to get it.
2. Spybot (or for that matter, Ad-Aware) doesn't always get all of these browser hijackers (that's what's bugging you) out. So, here's some additional stuff for you:
The Cleaner (free for 30 days)
CWShredder (freeware)
Hijack This! (free) NOTE: This app is very powerful and can easily foul everything up if you're not real careful. The link also includes detailed instructions for its use; READ THEM!
Then, wander over to the CNET Virus and Security Alerts Forum, especially if you have questions about Hijack This!
Hope this helps...
My Internet explorer homepage is now a different site and will not let me go back to the my original. Also pop ups for various adult sites keep popping up. I have tried ad-aware & spybot search and destroy and still nothing. What can I do

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic