Uninstalling/reinstalling generally doesn't help.
Are you sure it didn't make a new profile? Then see what happens if you link it to the old profile or copy the old profile into the new profile.
Or simply rename it (both in Appdata>Local and Appdata>Roaming, of course. Then surely it will make a new one. Then carefully copy the contents of your old corrupted profile into it and see what happens.
Toshiba laptop, Win7 SP1 500gb HD, 12gb RAM 64bit.
Thunderbird kept crashing, so I uninstalled and reinstalled it, but even though the profiles file was still there it does not see it, so I do not have access to my mail. Can anyone help me?