The app your using will know where the needed file is and load it on an as needed basis.
If you start moving things around you might make a mess.
W10 version......look at w10 pro just for gpedit and it's ability to block msft from feeding you stuff you don't want.
Why did you get that gpu?.....you could have got a gtx 1080 for about the same price and had far more video power.
I am building a desktop for Animation and 3d modeling/simulation. Currently I have a AMD Ryzen7, MSI BX470 MB, AMD WX7100 GPU, 32 Gig ddr4 RAM, 500 GIG SSD. If I get a large Disc drive 4-8Tera for file storage and use the SSD for software, will I have to manually move files to the SSD for optimum speed, or will the software automatically load the file while it is in use? I am also wondering which version of Win 10 would be best for what I will be doing.

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