There are a lot of machines that can't detect that size drive.
In short, you would use the 80 conductor IDE cable with the drive as CS jumpers on the black connection and the blue connection to the motherboard. The drive must "spin". Read http://www.pcguide.com/ref/hdd/if/ide/confCable80-c.html
If the BIOS is out of date, then there is hope but you must update it.
Alright, here's my problem (though I'm not exactly sure what it is):
Our computer worked fine until we moved, it was then it decided to quit operating properly. At this time I noticed that when it wouldn't boot it wasn't detecting the primary master. So I went into my BIOS and checked things out and I noticed that under my 'IDE Hard Drive' the option was set to 'none'. So then I went into the option list for my hard drive and the only other option was 'disabled'. So, in short I figured my hard drive had died on me. We were using a Fujitsu MPG3204AT with Windows XP Professional.
I went out to Office Max and bought a brand new Western Digital WD1200JBRTL (massive upgrade from the Fujitsu) and I'm still getting the same result when I start up my computer. The primary master is not detected and the same options are given in the BIOS.
Does anyone know what the problem might be?