it is Vista compatable?
Or is there a feature that your looking for thats not in handbrake?
there is a guide on there wiki http://trac.handbrake.fr/wiki/WindowsGuiGuide
worst problem for vista is you might have to give it admin rights.
Only thing handbrake does not do is rip commercial DVD's.. see wiki as to why. (since i don't know if forums allow talk of it, but just safer then sorry)