I've seen such tweaks to be in the game at times. Revese Look and so on. I don't know your game setup or game menus but I'd look there as well.
I have just bought a "Quantam QHMPL QHM7468" GamePad. It works fine with all the action games I'm having like BioShock Infinite, Batman: Arkham Origins, etc. But there is one minor problem, It's left stick is moving in opposite direction i.e. when I move it up protagonist in the game move backwards and when I move it down protagonist in the game move forward.
After installing the driver I got one application that allows testing the buttons, But it doesn't allow to configure the stick. Please anybody tell me how to overcome this problem.