May have a second session on the disc where extra software must be accessed in order for it to run. What software are you using to virtualize the disc as CD/DVD?
I've always had success using Clone Drive.
If I start the game (Prince of Persia: Warrior Within) with the DVD in the physical (external) drive, all works well. However, if I attempt to do so with only the disc image mounted, I get the "The game ended unexpectedly" error.
I'm on Windows 10 HP, I have tried using its native virtual machine as well as the Daemon Tools' one. I have tried remaking the image file and also installing the game from the image, rather than the physical disc. I have tried various compatibility settings.
None of it was successful, the problem persists, and clearly the ONLY difference between when it works and when not is whether I use the physical, or the virtual drive.
Strange indeed - I thought the application shouldn't be able to distinguish between the two cases.