Did I see what you said correctly, you have MSE and Avast running at the same time?
If so, I would uninstall one of those and just stick with the one. Two or more anti-virus suites running at the same time may cause such conflicts as they attempt to scan the same files at the same time.
I will let others reply about libusb0.sys if there is anything known about it. But are there any USB devices attached? If so, I would disconnect them. Or, have you updated any drivers at all for any devices?
I've had a pretty recent problem on my PC. It will randomly freeze up and won't respond to any kind of ctrl+alt+del commands or anything, forcing me to do a hard reset. When I boot back up, after I log into windows, it gets stuck on the loading screen (left it for half an hour)
I've used a sys restore and it will work fine, but it seems to start having problems when my system has to make a windows update (serivce pack I think) and when Security Essentials has to update as well. Because once I shut down to do those updates, the problems come back. I've also made sure to run MSE, Avast and Malewarebytes to see if it was a virus or malware, but all came back negative on my scans.
I've done a memtest86+ and no errors come back on the RAM, but I do have a pretty full event log which maybe someone is a bit more versed in. One person said it may be my PSU, and the fact that it's crappy, but others seem to say it's fine.
NVIDIA GeForce GTX 260
CPU: 4x, 2666 MHz
RAMPAGE II GENE
CPU, MB, SB, and NB temp and voltage are all normal and under threshold
My event log comes up with lots of: 219, 7060, 7001, 4, and 219. Some of them say something about a libusb0, but again, I don't quite know how to read them.
The system is about a year and a few months old, but I'd rather try and fix it myself so I can learn how, then send it back to ASUS.
Thanks, and let me know if you need me to provide any more info.