For example, all Windows 2000 CDs as well as most XP (Pro/Home) CDs will not install and support your 200GB USB 2.0 drive until patches, updates and in the case of Windows 2000, a registry change is made.
USB 1.1 support may be problematic since many USB drive cases omitted USB 1.1 support.
http://www.48bitlba.com notes part of the issues as well so you can get a complete picture of the problems.
I know some motherboards have problems supporting drives of large sizes. I was thinking of buying a 200 GB harddrive and throwing it in a USB 2.0 enclosure. I was wondering if it will be supported no matter what since it's coming in through the USB ports or will it still depend on my motherboard?