More clues are needed, but here's 2 issues:
1. Some find Explorer will take up % of the CPU when a complex wallpaper is used. Animated GIF or such.
2. The stuff your Antivirus doesn't test for that we call Pests and Parasites that the Anti-Parasite Suite (yes, you run all 5 tools) find at http://reviews.cnet.com/5204-6132-0.html?forumID=32&start=0 CWSHREDDER has a new website at http://www.spywareinfo.com/~merijn/cwschronicles.html
Bob
when I try to open any basic explorer window or try to go into the Explore option, my explorer suddenly jumps to 50%+ CPU usage and doesn't open up the window. Try and try again...nothing occurs until I max out my CPU usage. However, explorer has no issues running programs at all. PLZ help...McAfee says there isn't a virus...but I dunno. Plz help!

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic