First, remove any parasites. Read http://www.doxdesk.com/parasite/
Second, you didn't supply the error message so my response is generic.
When I start IE , this nagging error happens all the time.
What I discovered is that when I right click anywhere on my desktop and then open ActiveDesktop and then choose My current home page, the problem seems to go away.
I can serve the net.
If I reboot my computer, the problem resurface again.
I have no Idea what is going on.